SCIENTIFIC LITERATURE

Rationale for mechanism of DAVANAT" action based on mannan mechanism and is supported by the following peer-reviewed publications

Barondes et al., Cell 76, 597-598, 1994
Gabius, H.J., Biochem. Biophys. Acta 1071, 1, 1991
Kopeckova et al. Bioconjug. Chem. 12(6):890-9, 2001
Lehmann et al., Proc. Natl. Acad. Sci. USA 87, 6455-6459, 1990
Raz, A, and Lotan, R., Cancer Metastasis Review 6, 433, 1987
Regan et al., Proc. Natl. Acad. Sci. USA 83, 2248-2252, 1986
Platt D. and A. Raz, J. Natl. Cancer Inst. 84, 438-442, 1992

DAVANATTM Enhances the entry of 5-FU into the tumor cells and the antineoplastic effects of 5-FU while competing with 5-FU in the liver reducing the entry of 5-FU to liver cells. These modes of activities have been documented in a disposition study of 3H-DAVANATTM -1 in Both Tumor and Non-Tumor Bearing NCr-nu Mice.

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