SCIENTIFIC LITERATURE

Anticancer Res 1987 Jul-Aug;7(4B):829-32

Serum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration.

Campora E, Esposito M, Civalleri D, Gogioso L, Decian F, Balletto N, Falcone A, Nobile MT, Parodi B, Cafaggi S, et al.
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

Seven patients with advanced colon cancer, refractory to conventional chemotherapy, and malignant disease confined to the intra-abdominal space received a total of 24 consecutive courses of ip 5-Fluorouracil (5-FU). 5-FU 1000 mg was administered in 2 L of warm (37 degrees C) dialysate daily for five consecutive days every 28 days. 5-FU concentrations in serum, peritoneal fluid and urine were measured by high pressure liquid chromatography (HPLC). The mean disappearance half-life of 5-FU from the peritoneal fluid was 1.6 hours with a mean permeability area product (PA) of 22.4 ml/min. The mean peritoneal AUC was 450 +/- 165 times greater than the mean serum AUC. Ip 5-FU treatment is well tolerated, can be safely administered on an outpatient basis and produces a significant pharmacological advantage over conventional routes of administration

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