Cytoxan (generic name Ð cyclophosphamide) - has action leading to cross-linking of RNA of tumor cells, and thereby interferes with the growth of susceptible rapidly proliferating malignant cells. It is effective against a range of indications, such as malignant lymphomas, Hodgkin's disease, various leukemias, and cancer of the breast and ovaries. This drug is toxic with side effects that include nausea, vomiting, anorexia, diarrhea, skin rash and darkening and in extreme cases, heart damage, heart failure and secondary malignancies. It is manufactured by Bristol-Myers-Squibb Company for intravenous and oral administration.
